07 Jan 2020 WCPOS PARIS SEP 2019
Aniridia-associated keratopathy (AAK) physiopathology is a multidimensional condition involving not only limbal stem cell deficiency, but also a dysfunction in the eye’s tear film as well as changes in inflammatory mediators that lead progressively to the opacification of the ocular surface. This is the final message of the talk given by Neil Lagali, Associate Professor at Linköping University, at the World Congress of Paediatric Ophthalmology and Strabismus celebrated last September 2019 in Paris. Studies by he and his colleagues have revealed the activation of six different immunomodulators as well as reduced levels of IL1-RA, leading to a reduced tear production and increased tear film osmolarity in patients presenting AKK. This discovery contributes to the understanding of the biology of AKK progression and may be crucial in helping diagnosis and treatment decisions in aniridic patients.
#aniridia #aniridiaresearch #aniridiaawareness #COSTProgram
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